Senior Scientist l, QTAS & ADME Sciences

AbbVie is seeking a highly motivated and experienced scientist to join our Quantitative, Translation & ADME Sciences (QTAS) team in North Chicago. The ideal candidate will have a strong background and expertise with in vitro models, drug metabolizing enzyme function, drug-drug interaction concepts, quantitative bioanalysis and ability to spot, ideate and drive cutting-edge science. Applicants having experience in an adjacent area, such as drug permeability and transport, receptor pharmacology and pharmacokinetic modeling is desirable. In this exciting role, you will be expected to participate in implementing innovative and quantitative approaches to advance translational ADME using conventional as well as more complex in vitro models. Working primarily in a laboratory, the position will involve the conduct and contribution to scientific leadership of in vitro assays as well as applying translational modeling concepts to help drive the global in vitro ADME strategy at AbbVie. The candidate will be expected to qualify, confirm and evaluate new technologies as well as execute operational activities to support the mechanistic and translational understanding of early and late-stage small molecules to help advance drug candidates in our pipeline. In addition, you will have opportunities to contribute to broader areas within DMPK as your experience and expertise warrants.

 

Core responsibilities include:

• Laboratory experimentation in cellular and subcellular models
• Evaluating novel in vitro tools and methods, and apply established methods and concepts to enable and improve prediction of human PK and drug-drug interaction potential
• As needed, liaise with QTAS, discovery biology/pharmacology to generate data and knowledge supporting the build-up of translational, mechanistic models
• Communicate internally and externally on topics related to in vitro drug metabolism
• Keep up to date with emerging literature and science in modeling and in vitro approaches

Qualifications

• Bachelor’s Degree or equivalent education and typically 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary.
• Strong experience in cell culture methods, including hepatocytes and cell lines.
• Deep understanding of drug metabolism and ADME principles including enzyme kinetics, IVIVE and DDI risk assessment
• Strong and relevant publication record
• Highly motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable to work both as team player and independent scientific contributor
• Passion for generating ideas, learning, solving technical problems and applying new technologies to further scientific goals.

Key Leadership Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
• Ability to inspire and lead others in areas of your expertise
• Learns fast, grasps the "essence" and can change course quickly where indicated
• Raises the bar and is never satisfied with the status quo
• Creates a learning environment, open to suggestions and experimentation for improvement
• Embraces the ideas of others, nurtures innovation and manages innovation to reality

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this roleat  the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on manyfactors  including  geographic location, and we may ultimately  pay more or less than the posted range. This range may be  modified in the future. ​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to  participate in our short-term incentive programs. ​

Note: No amount of pay is  considered to be wages or compensation until such amount isearned,  vested,  and determinable. The amount and availability of  any bonus, commission, incentive, benefits, or any other form of compensation and benefits that areallocable to a   particular employee  remains in the Company's sole and absolute discretion unless and until paid and may be  modified at the Company’s sole and absolutediscretion,  consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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