Senior Scientist, Process Analytical Technologies

Job Description

We are seeking a Senior Scientist to join the Process Analytical Technologies (PAT) team within Analytical Enabling Capabilities (AEC). In this role, you will collaborate with a cross-functional, highly engaged team to advance the development pipeline and support commercial manufacturing. The successful candidate will lead the development, validation, and implementation of in-line, on-line, and at-line PAT solutions for both small- and large-molecule modalities. This position offers the opportunity to make a meaningful impact by advancing real-time analytical capabilities, enabling process monitoring and control, as well as supporting technology transfer and launch readiness efforts for programs progressing from early development into manufacturing.

Key responsibilities

• Develop, validate, and implement PAT methods (in-line, on-line, at-line) to monitor and control process parameters and product quality attributes.

• Support the systematic assessment and deployment of in-line, on-line, and at-line PAT methods across small- and large molecule programs.

• Deploy standardized analytical platforms to enable PAT implementation, including real-time monitoring and rapid shop-floor analytics.

• Support the scale-up activities and technology transfer of PAT applications to commercial manufacturing.

• Partner with capital project and facility teams to deploy integrated PAT infrastructure aligned with the launch preparedness strategy.

• Prepare and maintain scientific documentation and validation packages for PAT methods; contribute content for regulatory submissions.

Education guideline

• B.S. in chemistry, biochemistry, biotechnology, bioengineering, chemical engineering, or a related discipline with a minimum of 6 years of relevant industry experience; or

• M.S. with at least 4 years; or

• Ph.D. in a relevant discipline (expected completion no later than August 2026).

Required qualifications

• Technical background in spectroscopy (Raman, FTIR, NIR), chromatography, and chemometric/modeling approaches.

Preferred qualifications

• Experience supporting tech transfer, manufacturing scale-up, or regulatory filings.

• Proven track record of scientific contributions (peer-reviewed publications or equivalent technical outputs).

Attributes and competencies

• Strong collaborative and interpersonal skills; ability to work across functions and with external partners.

Required Skills:

Adaptability, Analytical Method Development, Bioanalytical Analysis, Biological Engineering, Biotechnology, Chemical Engineering, Chemical Technology, Chemistry, Chromatographic Techniques, Chromatography, Fourier-Transform Infrared Spectroscopy (FTIR), Innovative Thinking, Manufacturing Support, Near Infrared Spectroscopy (NIRS), Process Analytical Technology (PAT), Spectroscopy, Strategic Thinking, Technical Writing

Preferred Skills:

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.  As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.  For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement​

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

The salary range for this role is

$117,000.00 - $184,200.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits.  Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully 
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

No

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

1st - Day

Valid Driving License:

No

Hazardous Material(s):

laboratory chemicals

Job Posting End Date:

07/2/2026

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.