Research Associate 2

POSITION SUMMARY:

Join Natera’s R&D Scientific Operations as a Research Associate 2 on the Sample Processing team. You will execute Next-Generation Sequencing (NGS) workflows, cell-free DNA (cfDNA) extraction, and library preparation, generating the high-quality data required to advance our clinical diagnostic assays. Every sample represents a real person, and you will ensure accuracy, ethics, and compliance in sample management to directly impact patient care.

PRIMARY RESPONSIBILITIES:

• Isolate plasma and buffy coat from whole blood and normalize plasma samples
• Extract nucleic acids from whole blood or plasma using automated and manual extraction methods
• Perform library preparation for Next-Generation Sequencing (NGS) using automated and manual methods
• Determine the quantity and quality of nucleic acids using Quant-IT, Qubit, Nanodrop, BioAnalyzer, and qPCR
• Load libraries onto NGS platforms, including NextSeq, MiSeq i100, NovaSeq, NovaSeq X Plus, and Revio
• Interpret data to determine appropriate next steps based on rigorous outlined requirements
• Perform routine laboratory equipment maintenance as defined in Standard Operating Procedures (SOPs)
• Troubleshoot minor equipment malfunctions using data, escalating to the R&D equipment support team when necessary
• Track sample inventory and status using Laboratory Information Management Systems (LIMS) and Google Sheets
• Maintain precise records of lab work in LIMS, Google Sheets, Excel, and internal databases
• Periodically review or draft SOPs and other work instructions
• Take ownership of process improvements to increase operational precision and scale
• Think team by partnering directly with R&D staff to define process needs and execute lab work without needing translation layers
• Ensure accurate, ethical, and appropriate management of samples in compliance with all applicable federal regulations
• Adapt to evolving science and operational needs, executing tasks that move the work forward
• Handle protected health information (PHI) in paper and electronic formats as required to perform duties
• Complete required HIPAA/PHI privacy and security training within the first 30 days of hire and maintain current status on all training

QUALIFICATIONS:

• BS/BA in a biological science or equivalent
• Minimum of 2 years of related laboratory experience
• Must pass a post-offer criminal background check

KNOWLEDGE, SKILLS, AND ABILITIES:

• Extensive familiarity with good pipetting practices using single and multi-channel micropipettes and serological pipettes
• Direct hands-on experience with library preparation and NGS platforms
• Experience with laboratory automation systems (e.g., Tecan, Hamilton, Beckman-Coulter) is strongly preferred
• Able to operate independently in the lab with strict attention to detail and precision
• Proficiency with Laboratory Information Management Systems (LIMS) and database software
• Proficiency with Microsoft Office (Word, Excel) and Google Drive
• Clear, direct oral and written communication skills
• Ability to think analytically, testing assumptions with data to troubleshoot and solve problems
• Demonstrated strong interpersonal skills to build effective working relationships within the functional area
• Manage competing priorities while operating with pace and precision in an evolving scientific environment

PHYSICAL DEMANDS AND WORK ENVIRONMENT:

• Duties are typically performed in an office and laboratory setting daily
• Requires the ability to perform repetitive motions during pipetting and sample processing
• Requires the ability to use a computer keyboard, communicate over the telephone, and read printed material
• May require lifting or moving items weighing up to 25lbs