Principal Scientist, Functional Genomics

About the Role
Xaira is seeking a highly motivated and experienced Principal Scientist to join our Functional Genomics team with a focus on high-throughput perturbation platforms and single-cell genomics technologies. The ideal candidate will bring deep expertise in CRISPR-based screening approaches, perturb-seq, and large-scale functional genomics workflows, with experience generating high-quality datasets to support both therapeutic discovery and AI/ML modeling initiatives.

This position offers the opportunity to contribute to cutting-edge efforts at the intersection of functional genomics, machine learning, and disease biology. You will work closely with AI/ML scientists, computational biologists, automation engineers, and disease biology teams to develop scalable perturbation workflows, implement new technologies, and drive high-quality data generation and experimental innovation across multiple therapeutic areas.

Key Responsibilities

• Lead high-throughput perturbation and functional genomics efforts supporting therapeutic discovery and AI/ML-driven research initiatives
• Develop and implement advanced functional genomics technologies, including perturb-seq, CRISPRi/a, and single-cell omics workflows across complex cellular systems such as primary cells, differentiated cell types, and in vivo models
• Design, optimize, and scale screening workflows to improve throughput, reproducibility, data quality, and experimental robustness
• Collaborate closely with AI/ML scientists, computational biologists, automation engineers, and disease biology teams to integrate large-scale perturbation datasets into predictive modeling frameworks
• Contribute to scientific strategy, experimental design, protocol development, and prioritization across multiple programs and platform initiatives
• Present scientific findings and contribute to publications, patents, and scientific presentations while mentoring and providing scientific guidance to researchers within the organization

Qualifications

• Ph.D. in Immunology, Genomics, Molecular Biology, Bioengineering, or related scientific discipline with 10+ years of relevant industry and/or applied research experience
• Deep expertise in CRISPR-based screening approaches, perturb-seq, and single-cell RNA sequencing technologies, with a strong track record developing and scaling high-throughput functional genomics platforms
• Experience generating, analyzing, and interpreting large-scale perturbation datasets across complex cellular systems including primary cells, differentiated models, and organoid systems
• Familiarity with AI/ML applications in functional genomics and experience collaborating closely with computational and data science teams
• Demonstrated ability to independently lead scientific initiatives, drive cross-functional collaboration, and mentor scientists within multidisciplinary research environments
• Excellent analytical, organizational, written, and verbal communication skills, with the ability to thrive in fast-paced, highly collaborative environments focused on scientific innovation

Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity.  The base pay range for this position is expected to be $175,000 - $205,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.