Scientist I, ASO Process Development and Manufacturing

About This Role: 

 
We are seeking a highly motivated and creative individual to join our Oligonucleotide Chemical Development team as a Scientist I. This role is an exciting opportunity to develop robust processes for the synthesis of oligonucleotides, contributing significantly to both clinical and commercial therapeutics. You will gain hands-on experience in designing and developing manufacturing processes, working closely with our development and manufacturing teams. Your efforts will enhance process robustness, productivity, and impurity control, bringing substantial value to our work in oligonucleotide synthesis. As part of the larger Biogen structure, your contributions will play a pivotal role in advancing our scientific endeavors and impacting patient outcomes. 
 

What You’ll Do: 
• Collaborate with development and manufacturing teams to design and conduct laboratory experiments to optimize synthesis processes. 
• Perform ASO pilot-scale syntheses to support preclinical studies. 
• Accurately record experimental procedures and data. 
• Communicate research results effectively through writing reports and presenting in meetings. 
• Engage in CMC activities, including authoring CMC sections of INDs. 
 

Who You Are: 
You are passionate about exploring novel scientific ideas and eager to play a key role in developing cutting-edge technologies. Your vision aligns with Biogen’s state-of-the-art science in oligonucleotide synthesis, and you have a strong commitment to impacting patient lives positively. You thrive in a collaborative environment and are driven by a desire to innovate and contribute to scientific advancements. 

Required Skills: 
• M.S. with 0-2 years of relevant experience in pharmaceutical or biotech settings. 
• B.S with more than 3 years of relevant experience in pharmaceutical or biotech settings. 
• Specialization in synthetic organic chemistry, with excellent synthetic skills and a deep understanding of reactivity and reaction mechanisms. 
• Ability to work both independently and collaboratively, with effective communication skills in written and oral forms. 
• Self-driven, independent thinker, vigorous and thorough in experimentation and data interpretation. 

Preferred Skills: 
• Experience in nucleoside chemistry or oligonucleotide synthesis. 
• Perform synthetic process research and development of drug candidates and conjugates. 
• Continuous improvement mindset for research projects and synthesis processes. 

Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance. 

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being; including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement 
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance 
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit 
• 401(k) program participation with company matched contributions
• Employee stock purchase plan 
• Tuition reimbursement of up to $10,000 per calendar year 
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.